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. 2020 May 30;27(1):295–319. doi: 10.1007/s10741-020-09977-1

Fig. 2.

Fig. 2

Possible mechanism of anthracyclines action on renin-angiotensin-aldosterone system. Anthracyclines leads to increased levels of angiotensin II (ANG II), overexpression of angiotensin type 1 receptor (AT1R), and decreased expression of MasR and AT2R receptors. This is caused probably by affecting gene expression via reactive oxygen species (ROS), Erk1/2 kinases or heat shock transcription factor 2 (HSF2). All those changes lead to imbalance of cardioprotective and cardiotoxic factors in favor of cardiotoxic

HHS Vulnerability Disclosure