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. 2022 Jan 6;10(1):e003325. doi: 10.1136/jitc-2021-003325

Figure 5.

Figure 5

Intratumoral dominant cancer-specific T cell clones are potentially derived from non-sentinel LNs. (A) Frequencies of novel, expanded, persistent, and contracted clones; clones with TRB frequency >0.01 in tumors or sentinel LN are marked as triangle, others as circle. (B) Diffusion map of novel, expanded, persistent and contracted clones. (C) Diffusion map of activation and exhaustion scores. (D) Differentially expressed genes between novel and expanded, persistent and contracted clones. Significant DEGs were screened by p<0.05 and avg_FC>=2. DEGs, differentially expressed genes; LN, lymph nodes; TRB, T cell receptor beta locus.