Fig. 9.

Osteoclastic Panx1 deletion results in differential effects on bone cells in female and male Panx1^ΔOC mice. Schematic representation of the findings reported in this manuscript, with higher resorption in females and reduced formation in both males and females, resulting in reduced cancellous bone mass in 6-week-old growing mice. We hypothesize that, whereas the consequences of osteoclastic Panx1 deletion are primarily cell autonomous, the reduction in bone mass in male mice results from an altered osteoclast secretome leading to reduced osteoblast activity.