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. 2021 Dec 24;12:791095. doi: 10.3389/fimmu.2021.791095

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Copyright © 2021 Wilmore, Gaudette, Gómez Atria, Rosenthal, Reiser, Meng, Rosenfeld, Luning Prak and Allman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IgA⁺ BM plasma cells reside in the perivascular plasma cell niche. (A) Tibia from a B6.Blimp1^+/GFP mouse after fixation and clearing. (B) 3D confocal image of a cleared tibia from a B6.Blimp1^+/GFP female stained with CF568-anti-Laminin, CF647 anti-IgA and BV421 anti-IgM. (C) Using Imaris software, Blimp-GFP⁺ plasma cells were identified and sorted as IgA⁺ or IgA^- based on their mean fluorescent intensity (MFI) values for IgA. (D) A model of the original 3D image displaying the sorted IgA⁺ (gold) and IgA^- (green) plasma cells overlaid with Laminin⁺ vasculature.