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. 2021 Dec 30;5(3):e202101191. doi: 10.26508/lsa.202101191

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© 2021 Guo et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure S7. — ADAR1 gene deletion in EC-KO mice was monitored by two PCR reactions. The first reaction uses a mix of three primers (P1, P2, and P3, as shown in Fig 1), showing the relative quantity of deleted and floxed ADAR1 alleles. The deleted ADAR1 signal was not seen, indicating that relative to the undeleted ADAR1, the portion of deleted ADAR1 gene is very little. The second reaction uses only primer P1 and P3, which only amplifies the deleted ADAR1 allele. ADAR1 deletion is detected in all tissues tested, with strong signals in the lung (Lu), kidney (K), and heart (H), whereas a minimum signal was seen in the brain (Br) and liver (Lv) tissues.