Figure 4. Negative correlation between gene expression and splicing divergence.

(A) Comparison of average gene expression level of genes with “Some-Divergent” events in divergent tissues versus non-divergent tissues, the number in parentheses is the number of “Some-Divergent” events (One-sided Wilcoxon signed-rank test). (B) Distribution of Spearman’s correlation coefficients between |ΔPSI| and gene expression across tissues for events expressed in ≥3 tissues and divergent in ≥1 tissue(s) (one-sided Wilcoxon signed-rank test). Box plot elements: center line, median; box limits, lower and upper quartiles; whiskers, lowest and highest value within 1.5 IQR. n.s., not significant; *P < 0.05; **P < 0.01; ***P < 0.001.