Figure S12. Sequence conservation and average percent dominant isoform (PDI) between tissue-regulatory patterns, divergent patterns between tissues.

(A) Sequence conservation of regions around splicing sites of Non-Differential and Switch-Like events. Events expressed in two or more tissues and with exon size ≥60 bp and intron size ≥200 bp were used. The mean PhastCons score of each position across events within the same tissue-regulatory group for exonic regions (including 30 bp at both 5′ and 3′ end of alternative exon) and intronic regions (200-bp flanking sequences on each side) around alternative splicing sites was compared between Non-Differential events with high PDI (PDI > 0.9) and Non-Differential events with low PDI (PDI ≤ 0.9) and Switch-Like events. (B) Comparison of average PDI of events in the five tissue-regulatory groups. (C) Stacked bar plot shows the proportion of allelic divergence patterns between two tissues. Only events expressed in the selected tissue (indicated below each bar) and one other tissue are used. Proportions of four allelic divergence patterns are indicated with different colors within each bar.