Table 1.

Seven identified genome-wide gene-air pollution interaction signals Note: CAF = Coded Allele Frequency, INFO = Imputation quality, AP = Air Pollutant, LF = Lung Function, BP = Base Position. A negative BETA (interaction effect) suggests a more deleterious effect on lung function per unit increase of air pollutant as the coded allele increases. A positive BETA (interaction effect) suggests a more protective effect. Interaction effect is per 10 μg/m³ increase in air pollutant NO₂ and per 5 μg/m³ increase for air pollution variables PM₁₀ and PM_2.5 as the coded allele increases. Lung function effects are the product of the BETA value and the observed standard deviation of the lung function trait within the analysed sample.

LF trait	AP	SNP	CHR	BP	Coded allele	Non-Coded allele	CAF	INFO	BETA	SE	BETA effect in units of LF (ml for FEV1, FVC or percentage points for FEV1/FVC)	P	Locus
FVC	PM10	rs74048016	1	1,068,280	C	G	0.98	0.97	−0.139	0.025	−133.1	3.83 $\times$ 10-8	C1orf159 (dist = 16811), LINC01342 (dist = 4117)
FEV1	PM10	rs28666788	4	188,078,645	G	A	0.096	0.99	−0.065	0.012	−49.2	3.92 $\times$ 10-8	FAT1 (dist = 433635), LINC02374 (dist = 44495)
FVC	PM2.5	rs192415220	5	137,726,002	C	T	0.006	0.94	−0.479	0.087	−459.3	3.96 $\times$ 10-8	KDM3B
FEV1/FVC	PM10	rs137914543	6	6,414,006	G	GTCTC	0.06	0.83	−0.101	0.016	−0.65	3.55 $\times$ 10-10	LY86-AS1
FEV1	PM2.5	rs138235384	7	125,969,169	C	T	0.994	0.90	−0.466	0.085	−352.1	4.10 $\times$ 10-8	LOC101928283 (dist = 949794), GRM8 (dist = 109483)
FEV1	PM10	rs762101031	19	29,112,275	CAAT	C	0.96	0.79	−0.120	0.022	−90.5	2.87 $\times$ 10-8	LOC100420587
FEV1	NO2	rs2825255	21	20,362,376	T	C	0.83	1.00	−0.027	0.005	−20.6	2.53 $\times$ 10-9	MIR548XHG (dist = 230246), LINC01683 (dist = 903217)
FVC									−0.025	0.005	−24.2	3.52 $\times$ 10-8