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. 2021 Nov 9;27(1):e12889. doi: 10.1111/anec.12889

TABLE 4.

Hydrophobicity, transmembrane domain, and phosphorylation analyses

KCNH2
		302	303	304	305	306	307	308	309	310	311	312	313
Amino acid	WT	I	C	V	M	L	I	G	S	L	M	Y	A
Amino acid	p.307_308del	I	C	V	M	L	D	‐	S	L	M	Y	A
Hydrophobicity	WT	2.167	3.100(max)	2.556	2.156	2.667	2.378	1.956	1.689	1.389	1.467	1.278	1.278
Hydrophobicity	p.307_308del	2.167	2.211	1.622	1.733	2.033	1.389	‐	1.311	0.756	1.044	0.933	1.278
Transmembrane	WT	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix
Transmembrane	p.307_308del	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix	TMhelix
Phosphorylation	WT								Yes
Phosphorylation	p.307_308del								No

SCN5A
		1858	1859	1860	1861	1862	1864	1865	1866	1867	1868	1869	1870
Amino acid	WT	I	T	T	T	L	R	K	H	E	E	V	S
Amino acid	p.R1865H	I	T	T	T	L	H	K	H	E	E	V	S
Hydrophobicity	WT	−0.033	−0.111	−0.522	−0.878	−0.922	−1.989	−2.300	−1.756	−1.767	−1.989	−1.278	−0.311
Hydrophobicity	p.R1865H	−0.033	−0.111	−0.522	−0.733	−0.778	−1.844	−2.156	−1.611	−1.622	−1.844	−1.133	−0.311
Transmembrane	WT	outside	outside	outside	outside	outside	outside	outside	outside	outside	outside	outside	outside
Transmembrane	p.R1865H	outside	outside	outside	outside	outside	outside	outside	outside	outside	outside	outside	outside
Phosphorylation	WT				Yes	Yes
Phosphorylation	p.R1865H				Yes	Yes