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. 2022 Jan 6;15:6. doi: 10.1186/s12920-022-01155-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Histologic findings of SC cases. A Case 1; B–D Case 2; E and F, Case 3 (H&E*). A A tumor consisting mainly of a papillary-cystic growth pattern containing follicular structures. B Low-power view of the biphasic histology of the tumor comprising a HG carcinoma with a solid proliferative component (right portion), and a conventional LG SC with a papillary-cystic component (left portion). The LG component consisted of small, regular cells with an eosinophilic or vesicular cytoplasm (C), whereas the HG component consisted of enlarged, irregularly sized cells with prominent nucleoli, and several mitoses (arrows) can also be observed (D). E Histologic findings of the initial tumor exhibiting the characteristics of LG SC, consisting of tumor cells with unifying nuclear features accompanied with many microcystic structures containing eosinophilic secretions. F Histologic findings in the specimen from the 6th recurrence exhibiting the characteristics of a HG carcinoma, consisting of irregular, enlarged cells containing large pleomorphic nuclei and prominent nucleoli with high mitotic activity (arrows). Scale bars, 100 µm (A, E, F); 500 µm (B); 50 µm (C, D). *Hematoxylin and eosin