Table 2.
Dosimetric characteristics of patients experiencing selected grade 2–3 toxicities from repeat SABR and CRT
| Organ at risk (OAR) | Grade and number (%) of re-SABR toxicity | Composite BED3 or % corresponding to Re-SABR toxicity, mean (range) | Grade and number (%) of re-CRT toxicity | Composite BED3 or % corresponding to toxicity, mean (range) |
|---|---|---|---|---|
| Brachial plexus | ||||
|
Dmax D0.2 cc |
Grade 2 brachial plexopathy, n = 1 (7%) |
144 Gy 123 Gy |
- | - |
| Chest wall | ||||
|
Dmax D30cc D50cc |
Grade 2 rib fracture, n = 3 (21%) |
370 Gy (288–432) 225 Gy (166–339) 187 (122–308) |
Grade 2 rib fracture, n = 2 (8%) |
403 Gy (353–452) 209 Gy (175–243) 139 (100–177 Gy) |
| Chest wall | ||||
|
Dmax D30cc D50cc |
Grade 2 chest wall pain, n = 1 (7%) |
411 Gy 107 Gy 83 Gy |
Grade 2 chest wall pain, n = 3 (13%) |
386 Gy (353–452) 243 Gy (175–310) 177 Gy (100–255) |
|
Dmax D30cc D50cc |
Grade 3 chest wall pain, n = 1 (7%) |
390 Gy 339 Gy 308 Gy |
- | - |
| Total Lung | ||||
|
Mean Dmax V5 V20 V35 Mean Dmax V5 V20 V35 |
Grade 2 pneumonitis, n = 1 (7%) Grade 3 pneumonitis, n = 1 (7%) |
15 Gy 451 Gy 32% 13% 10% 35 Gy 481 Gy 32% 23% 20% |
Grade 2 pneumonitis, n = 1 (4%) Grade 3 pneumonitis, n = 2 (8%) |
29 Gy 382 Gy 67% 33% 25% 21 Gy (20–22) 391 (332–449) 36% (34–37) 24% (23–25) 19% (18–19) |
| Total lung | ||||
|
Mean Dmax V5 V20 V35 |
Grade 2 dyspnea, n = 3 (21%) |
24 Gy (11–33) 487 Gy (377–622) 49% (23–77) 27% (11–45) 17% (7–25) |
Grade 2 dyspnea, n = 2 (8%) |
33 Gy (32–34) 444 Gy (362–526) 62% (55–68) 36% (30–41) 28% (24–31) |
|
Mean Dmax V5 V20 V35 |
Grade 3 dyspnea, n = 1 (7%) |
35 Gy 481 Gy 32% 23% 20% |
Grade 3 dyspnea, n = 2 (8%) |
26 Gy (22–29) 416 Gy (382–449) 52% (37–67) 28% (23–33) 22% (19–25) |