Fig. 3.

Motor dysfunction in mice injected intrathecally with a SARM1^V184G AAV construct. Average time suspended from an inverted screen (maximum 120 s) for C57BL/6 mice injected with a human SARM1 reference allele (n = 8) or SARM1^V184G (n = 7) AAV compared to uninjected controls (n = 3) 3, 9 and 12 weeks post-injection. *p < 0.005 difference from both the reference allele and uninjected controls. These results demonstrate that infection with SARM1^V184G causes persistent motor dysfunction while the control SARM1 construct does not