Figure 3.

Summary of reported changes in glycosylation as PCa progresses: As PCa develops, high mannose and complex biantennary N-glycans become prevalent, with frequent core fucosylation and a2-3 sialylation of complex forms, Furthermore, increased O-GlcNAcylation and altered expression of glycosyltransferases, glycoconjugates and galectins occurs. As PCa becomes metastatic, increased branching of N-Glycans and alterations in O-Glycans occurs with frequent expression of sialyl lewis X and Y antigens. In addition to changes in glycosyltransferases, glycoconjugates and galectin expression, glycolipids GM1b and GD1a have been reported to be increased. Created with BioRender.com.