Table 1. Baseline Characteristics of the Study Patientsa.
| Characteristic | 5-d Regimen (n = 293) | 1-d Regimen (n = 311) | Total (n = 604) |
|---|---|---|---|
| Patient demographic characteristics and tumor details | |||
| Age, mean (SD), y | 42.6 (21.7) | 39.9 (22.0) | 41.2 (21.9) |
| Sex | |||
| Male | 178 (60.8) | 183 (58.8) | 361 (59.8) |
| Female | 115 (39.2) | 128 (41.2) | 243 (40.2) |
| Race and ethnicity | |||
| Asian | 54 (18.4) | 60 (19.4) | 114 (18.9) |
| Black | 21 (7.2) | 22 (7.1) | 43 (7.1) |
| Hispanic | 14 (4.8) | 20 (6.5) | 34 (5.6) |
| Indigenous | 4 (1.4) | 11 (3.6) | 15 (2.5) |
| White | 194 (66.2) | 190 (61.5) | 384 (63.8) |
| Otherb | 6 (2.0) | 6 (1.9) | 12 (2.0) |
| Unknown | 0 | 2 | 2 |
| Systemic metastases | |||
| No | 244 (83.3) | 255 (82.0) | 499 (82.6) |
| Yes | 49 (16.7) | 56 (18.0) | 105 (17.4) |
| Other cancer treatment modalities | |||
| No | 157 (53.6) | 138 (44.4) | 295 (48.8) |
| Yes | 136 (46.4) | 173 (55.6) | 309 (51.2) |
| Preoperative chemotherapy | 129 (44.0) | 161 (51.8) | 290 (48.0) |
| Preoperative radiation | 10 (3.4) | 12 (3.9) | 22 (3.6) |
| Other | 7 (2.4) | 7 (2.3) | 14 (2.3) |
| Location of tumor | |||
| Tibia | 53 (18.1) | 55 (17.7) | 108 (17.9) |
| Femur | 240 (81.9) | 256 (82.3) | 496 (82.1) |
| Type of tumor | |||
| Bone tumor | 237 (80.9) | 249 (80.1) | 486 (80.5) |
| Soft tissue sarcoma | 28 (9.6) | 34 (10.9) | 62 (10.3) |
| Oligometastatic bone disease | 28 (9.6) | 28 (9.0) | 56 (9.3) |
| Neutropenia at time of surgeryc | |||
| No. of patients | 275 | 286 | 561 |
| No | 231 (84.0) | 234 (81.8) | 465 (82.9) |
| Yes | 44 (16.0) | 52 (18.2) | 96 (17.1) |
| Surgical and perioperative management details | |||
| Length of procedure, median (Q1-Q3), min | 270 (206-377) | 270 (200-377) | 270 (205-377) |
| Antibiotic or silver-coated prosthesis | |||
| No. of patients | 292 | 311 | 603 |
| No | 276 (94.5) | 295 (94.9) | 571 (94.7) |
| Yes | 16 (5.5) | 16 (5.1) | 32 (5.3) |
| Antibiotic | 6 (2.1) | 6 (1.9) | 12 (2.0) |
| Silver-coated prosthesis | 10 (3.4) | 10 (3.2) | 20 (3.3) |
| Suction drain used | |||
| No. of patients | 293 | 310 | 603 |
| No | 63 (21.5) | 74 (23.9) | 137 (22.7) |
| Yes | 230 (78.5) | 236 (76.1) | 466 (77.3) |
Abbreviation: Q1-Q3, quartile 1 to quartile 3.
a
Data are presented as number (percentage) of patients unless otherwise indicated.
b
Other ethnicity includes Middle Eastern (n = 3), mixed race (n = 5), North African (n = 2), Polynesian (n = 1), and Turkish (n = 1).
c
Absolute neutrophil count of 1500/μL or less (to convert to ×109/L, multiply by 0.001).