FIG. 2.

(A) A simplified summary of the players during the tissue repair process and their dynamic interactions. MC progenitors are recruited into the tissue and differentiate into mature, granulocytic MCs. Growth factors, cytokines, and other signaling molecules released by other players in the wound healing process stimulate MCs to release their granules. These granules help orchestrate the inflammatory process. (B) A schematic of a typical MC response to a biomaterial designed for implantation. Color images are available online.