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. 2021 Dec 24;13:752575. doi: 10.3389/fnagi.2021.752575

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Copyright © 2021 Pham, Sasabayashi, Takahashi, Takayanagi, Kubota, Furuichi, Kido, Noguchi and Suzuki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pairwise group comparisons of longitudinal local gyrification index (LGI) changes. Cortical statistical maps showed that the schizophrenia (Sz) group exhibited a significantly greater decline in LGI over time than the healthy control (HC) group in the caudal middle frontal gyrus, superior frontal gyrus, and pars opercularis gyrus bilaterally, in addition to the rostral middle frontal gyrus, pars triangularis gyrus, and caudal anterior cingulate cortex in the left hemisphere, and superior temporal gyrus, precentral gyrus in the right hemisphere (A). The progressive increase in LGI in the left superior frontal area was smaller in the schizotypal (SzTypal) group than in the HC group (B). The decline in LGI in the right pre- and post-central gyrus, supramarginal gyrus, and transverse temporal gyrus was greater in the Sz group than in the SzTypal group (C).