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Zanubrutinib concentrations in plasma and CSF.
| Interval between administration and sampling | Sample | Mean concentration(pg/ml) | P-value | |
|---|---|---|---|---|
| Plasma | 2 h | 10 | 182909.3 ± 91077.1 | 0.193 |
| 3 h | 13 | 125813.7 ± 91605.7 | ||
| entire series | 23 | 143190.6 ± 93302.7 | ||
| CSF | 2 h | 10 | 4117.0 ± 2864.3 | 0.192 |
| 3 h | 13 | 2426.6 ± 2028.0 | ||
| entire series | 23 | 2941.1 ± 2382.01 | ||
| Corrected CSF/plasma ratio (%) | 2 h | 10 | 41.2 ± 32.5 | 0.869 |
| 3 h | 13 | 43.3 ± 26.5 | ||
| entire series | 23 | 42.7 ± 27.7 |
