Table 2.
Summary results of the meta-analyses.
Outcomes of interest | Studies, n | RG | LG | OR (95%CI) | P-value | Heterogeneity | |||
---|---|---|---|---|---|---|---|---|---|
χ 2 | df | I 2, % | P-value | ||||||
Short-term outcomes | |||||||||
Operative time (min) | 17 | 4,993 | 5,461 | 39.97 (31.15, 48.79) | <0.00001 | 415.92 | 16 | 96 | <0.00001 |
Blood loss (ml) | 16 | 4,925 | 5,393 | -15.87 (-23.35, -8.39) | <0.0001 | 63.05 | 15 | 76 | <0.00001 |
Proximal resection margin (cm) | 6 | 1,117 | 1,319 | -0.02 (-0.20, 0.17) | 0.85 | 4.75 | 5 | 0 | 0.45 |
Distal resection margin (cm) | 6 | 1,117 | 1,319 | 0.07 (-0.13, 0.27) | 0.51 | 5.71 | 5 | 12 | 0.34 |
Number of retrieved lymph node | 16 | 5,004 | 5,837 | 1.75 (0.90, 2.60) | <0.0001 | 50 | 15 | 70 | <0.0001 |
Overall complications | 17 | 4,823 | 5,292 | 0.81 (0.72, 0.91) | 0.0003 | 22.65 | 16 | 29 | 0.12 |
Major complications | 17 | 4,780 | 5,249 | 0.67 (0.55, 0.82) | 0.0001 | 15.07 | 16 | 0 | 0.52 |
Conversion rate | 4 | 2,301 | 2,567 | 0.66 (0.40, 1.07) | 0.09 | 1.76 | 3 | 0 | 0.62 |
Anastomosis site leakage | 14 | 4,474 | 4,943 | 0.93 (0.67, 1.29) | 0.67 | 10.27 | 13 | 0 | 0.67 |
Ileus | 12 | 4,424 | 4,893 | 0.82 (0.52, 1.28) | 0.38 | 7.69 | 11 | 0 | 0.74 |
Abdominal bleeding | 12 | 4,001 | 4,470 | 0.66 (0.41, 1.07) | 0.09 | 6.60 | 11 | 0 | 0.83 |
Anastomotic stenosis | 5 | 2,630 | 2,630 | 1.00 (0.48, 2.08) | 1.00 | 2.92 | 4 | 0 | 0.57 |
Duodenal stump leakage | 6 | 3,192 | 3,458 | 0.88 (0.53, 1.45) | 0.61 | 2.93 | 5 | 0 | 0.69 |
Reoperation | 5 | 1,197 | 1,464 | 0.63 (0.33, 1.20) | 0.16 | 1.21 | 4 | 0 | 0.95 |
Time to first flatus (day) | 12 | 4,270 | 4,538 | -0.14 (-0.22, -0.07) | 0.0003 | 31.32 | 11 | 65 | 0.001 |
Time to oral intake (day) | 15 | 4,604 | 5,673 | -0.12 (-0.18, -0.06) | 0.0001 | 17.53 | 14 | 20 | 0.23 |
Length of stay (day) | 18 | 5,765 | 6,562 | -0.31 (-0.47, -0.15) | 0.0001 | 22.58 | 17 | 25 | 0.16 |
Cost (USD) | 4 | 2,255 | 2,723 | 0.34 (0.32, 0.36) | <0.00001 | 3.32 | 3 | 10 | 0.34 |
Oncological outcomes | |||||||||
OS | 7 | 3,475 | 4,106 | 0.96 (0.86, 1.07) | 0.50 | 3.06 | 6 | 0 | 0.80 |
RFS | 5 | 2,732 | 2,732 | 0.98 (0.80, 1.21) | 0.85 | 2.29 | 4 | 0 | 0.68 |
RG, robotic gastrectomy; LG, laparoscopic gastrectomy; MD, mean difference; OR, odds ratio; CI, confidence interval.