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. 2021 Dec 24;11:759509. doi: 10.3389/fonc.2021.759509

Table 2.

Summary results of the meta-analyses.

Outcomes of interest Studies, n RG LG OR (95%CI) P-value Heterogeneity
χ 2 df I 2, % P-value
Short-term outcomes
Operative time (min) 17 4,993 5,461 39.97 (31.15, 48.79) <0.00001 415.92 16 96 <0.00001
Blood loss (ml) 16 4,925 5,393 -15.87 (-23.35, -8.39) <0.0001 63.05 15 76 <0.00001
Proximal resection margin (cm) 6 1,117 1,319 -0.02 (-0.20, 0.17) 0.85 4.75 5 0 0.45
Distal resection margin (cm) 6 1,117 1,319 0.07 (-0.13, 0.27) 0.51 5.71 5 12 0.34
Number of retrieved lymph node 16 5,004 5,837 1.75 (0.90, 2.60) <0.0001 50 15 70 <0.0001
Overall complications 17 4,823 5,292 0.81 (0.72, 0.91) 0.0003 22.65 16 29 0.12
Major complications 17 4,780 5,249 0.67 (0.55, 0.82) 0.0001 15.07 16 0 0.52
Conversion rate 4 2,301 2,567 0.66 (0.40, 1.07) 0.09 1.76 3 0 0.62
Anastomosis site leakage 14 4,474 4,943 0.93 (0.67, 1.29) 0.67 10.27 13 0 0.67
Ileus 12 4,424 4,893 0.82 (0.52, 1.28) 0.38 7.69 11 0 0.74
Abdominal bleeding 12 4,001 4,470 0.66 (0.41, 1.07) 0.09 6.60 11 0 0.83
Anastomotic stenosis 5 2,630 2,630 1.00 (0.48, 2.08) 1.00 2.92 4 0 0.57
Duodenal stump leakage 6 3,192 3,458 0.88 (0.53, 1.45) 0.61 2.93 5 0 0.69
Reoperation 5 1,197 1,464 0.63 (0.33, 1.20) 0.16 1.21 4 0 0.95
Time to first flatus (day) 12 4,270 4,538 -0.14 (-0.22, -0.07) 0.0003 31.32 11 65 0.001
Time to oral intake (day) 15 4,604 5,673 -0.12 (-0.18, -0.06) 0.0001 17.53 14 20 0.23
Length of stay (day) 18 5,765 6,562 -0.31 (-0.47, -0.15) 0.0001 22.58 17 25 0.16
Cost (USD) 4 2,255 2,723 0.34 (0.32, 0.36) <0.00001 3.32 3 10 0.34
Oncological outcomes
OS 7 3,475 4,106 0.96 (0.86, 1.07) 0.50 3.06 6 0 0.80
RFS 5 2,732 2,732 0.98 (0.80, 1.21) 0.85 2.29 4 0 0.68

RG, robotic gastrectomy; LG, laparoscopic gastrectomy; MD, mean difference; OR, odds ratio; CI, confidence interval.