Table 1.
Descriptive characteristic of the whole cohort of patients [No. 1,147].
| MFI | Mixed factor | Overall | |
|---|---|---|---|
| n = 791 | n = 356 | n = 1147 | |
| Age (years) | |||
| Median (IQR) | 37 (34-40) | 37 (34-41) | 37 (34-41) |
| BMI (kg/m2) | |||
| Median (IQR) | 25 (23-27) | 25 (23-27) | 25 (23-27) |
| CCI - n (%) | |||
| 0 | 748 (95) | 332 (93) | 1080 (94) |
| 1 | 21 (3) | 12 (3) | 33 (3) |
| 2+ | 22 (3) | 12 (3) | 34 (3) |
| Mean testicular volume (Prader) | |||
| Median (IQR) | 15 (12-20) | 15 (12-20) | 15 (12-20) |
| Total testosterone (ng/ml) | |||
| Median (IQR) | 4 (3-6) | 5 (3-6) | 4 (3-6) |
| FSH (mU/mL) | |||
| Median (IQR) | 6 (3-13) | 5 (3-10) | 6 (3-11) |
| Sperm concentration (106/ml) | |||
| Median (IQR) | 4 (0-24) | 9 (1-35) | 6 (0-26) |
| Varicocele - n (%) | |||
| No | 423 (53) | 191 (54) | 614 (54) |
| Yes | 368 (47) | 165 (46) | 533 (46) |
| Cryptorchidism - n (%) | |||
| No | 703 (89) | 326 (92) | 1029 (90) |
| Yes | 88 (11) | 30 (8) | 118 (10) |
| Karyotype abnormalities - n (%) | |||
| Normal | 499 (93) | 233 (95) | 732 (94) |
| XXY | 12 (2) | 5 (2) | 17 (2) |
| Other abnormalities | 24 (4) | 7 (3) | 31 (4) |
| CFTR - n (%) | |||
| Normal | 788 (100) | 356 (100) | 1144 (100) |
| Mutation | 3 (0) | 0 (0) | 3 (0) |
| Y chromosome microdeletions - n (%) | |||
| Normal | 780 (99) | 355 (100) | 1135 (99) |
| Deletion | 11 (1) | 1 (0) | 12 (1) |
| Cause of infertility - n (%) | |||
| Idiopathic | 142 (18) | 77 (22) | 219 (19) |
| Genetic abnormalities | 48 (6) | 13 (4) | 61 (5) |
| Cryptorchidism | 73 (9) | 25 (7) | 98 (9) |
| Obstructive | 16 (2) | 5 (1) | 21 (2) |
| Hypogonadism | 295 (38) | 125 (35) | 420 (37) |
| Varicocele | 199 (25) | 105 (30) | 304 (27) |
| Other | 11 (1) | 3 (1) | 14 (1) |
The study cohort is stratified according to the presence of an isolated male factor infertility (MFI) or a mixed factor (MFI + female factor).
BMI, body mass index; CCI, Charlson comorbidity index; CFTR, cystic fibrosis conductance regulator; FSH, follicle stimulating hormone.