Table 2.
Univariate and multivariate logistic regression analysis of prediction of MVI in training cohort.
| Characteristics | Univariate Logistic regression analysis | Multivariate Logistic regression analysis | |||
|---|---|---|---|---|---|
| OR (95%CI) | P-value | OR(95%CI) | P-value | ||
| Gender | Male vs Female | 1.385 (0.730, 2.626) | 0.318 | – | |
| Age (years) | ≥65 vs <65 | 1.757 (0.974, 3.169) | 0.061 | – | |
| With hepatitis | Present vs Absent | 1.284 (0.682, 2.418) | 0.439 | – | |
| With Cirrhosis | Present vs Absent | 1.399 (0.784, 2.496) | 0.255 | – | |
| AFP (ng/ml) | >400 vs ≤400 | 4.405 (2.581, 7.518) | <0.001 | 4.327 (1.803, 10.384) | 0.001 |
| AST (U/L) | <45 45–90 vs <45 >90 vs <45 |
Control 2.564 (1.419, 4.633) 4.555 (1.735, 11.958) |
<0.001 0.002 0.002 |
– | 0.195 |
| ALT (U/L) | <40 40–80 vs <40 >80 vs <40 |
Control 1.024 (0.592, 1.770) 1.660 (0.773, 3.567) |
0.420 0.933 0.194 |
– | |
| Total bilirubin (umol/L) | >17.1 vs ≤17.1 | 1.216 (0.750, 1.970) | 0.428 | — | |
| Direct bilirubin (umol/L) | >3.4 vs ≤3.4 | 1.302 (0.751, 2.258) | 0.347 | — | |
| Total protein (g/L) | <65 vs ≥65 | 1.461 (0.901, 2.370) | 0.124 | — | |
| Serum albumin (g/L) | <40 vs ≥40 | 1.077 (0.662, 1.754) | 0.764 | — | |
| Neutrophils (109/L) | >6.30 vs ≤6.30 | 1.081 (0.521, 2.241) | 0.835 | — | |
| Platelet (109/L) | <125 vs ≥125 | 1.151 (0.708, 1.871) | 0.571 | — | |
| Lymphocyte (109/L) | <1.10 vs ≥1.10 | 3.267 (1.965, 5.432) | <0.001 | 2.747 (1.193, 6.328) | 0.018 |
| VEGF-A (pg/ml) | >138.30 vs ≤138.30 | 21.125 (11.264, 39.619) | <0.001 | 33.088 (12.871, 85.057) | <0.001 |
| Tumor size (cm) | <3 3–5 vs <3 >5 vs <3 |
Control 1.071 (0.490, 2.344) 5.523 (2.687, 11.312) |
<0.001 0.863 <0.001 |
– | 0.954 |
| Peritumoral enhancement | Present vs Absent | 7.725 (4.473, 13.341) | <0.001 | 2.415(1.009, 5.781) | 0.048 |
| Peritumoral boundary | Clear boundaryvs Unclear boundary | 3.062 (1.832, 5.119) | <0.001 | — | 0.502 |
| Tumor shape | Regular shape vs Irregular shape |
5.468 (3.173, 9.425) | <0.001 | 3.504(1.478, 8.307) | 0.004 |
| Intratumoral artery | Present vs Absent | 12.508 (7.004, 22.337) | <0.001 | 7.121(2.830, 17.922) | < 0.001 |
| Multiple tumors | Present vs Absent | 2.712 (1.019, 7.220) | 0.046 | — | 0.084 |