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Brain magnetic resonance imaging scans of the patient with SPG4. Images were obtained when the patient was 5 (a, c) and 16 (b, d) years old, respectively. Axial T2-weighted (a, b) and coronal T2-FLAIR (c, d) images show right hippocampal atrophy (arrows). Note that the right hippocampal atrophy was already observed before the onset of epilepsy.
