Table 3.
Impact of treatment on known bacterial causes of diarrhoea
| Bacteria | Ba | SEb | Adjusted p-value |
|---|---|---|---|
| Aeromonas | − 0.077 | 0.162 | 0.9668 |
| Campylobacter jejuni | 0.717 | 0.289 | 0.2271 |
| Escherichia coli | 1.047 | 0.391 | 0.1599 |
| Non-typhoid Salmonellac | 0.255 | 0.186 | 0.7767 |
| Shigella | 0.114 | 0.599 | 0.9910 |
| Any pathogen | 1.001 | 0.334 | 0.0845 |
The GEMS study specifically identified enteroaggregative (EAEC), enteropathogenic (EPEC) and enterotoxigenic (ETEC) E. coli strains as primary causes of diarrhoea. More than 90% of E. coli reads here could not be classified at the strain-level; approximately 300,000 E. coli reads could be classified to the strain level and were analysed further. All three pathogens showed a trend towards increased abundance in treated children, significantly for EPEC (p = 0.0001, EAEC; p = 0.2970, ETEC; p = 0.8835)
aβ = regression coefficient
bSE = standard error
cthe only non-typhoid Salmonella identified was S. enterica