Table 2.

Univariate and Multivariate Cox proportional hazards analysis of OS

Variable	Univariate			Multivariate
	HR	95%CI	p-value	HR	95%CI	p-value
Age (> 60/ ≤ 60)	1.851	1.455–2.675	0.002*	1.524	0.808–2.876	0.193
Gender (Female/Male)	1.107	0.789–1.535	0.543
Grade (High/Low)	2.867	0.709–11.588	0.139
Tumor depth (T3–T4/T0–T2)	2.203	1.509–3.217	< 0.001*	2.597	0.841–8.023	0.097
Lymph node (N1–N3/N0)	2.359	1.723–3.230	< 0.001*	1.711	0.972–3.012	0.063
Distant metastasis (M1/M0)	3.306	1.580–6.917	0.002*	1.63	0.615–4.325	0.326
Clinical stage (III + IV/I + II)	2.288	1.573–3.328	< 0.001*	1.51	0.443–5.146	0.51
ANXA1 (High/Low)	1.973	1.455–2.675	< 0.001*	2.34	1.403–3.909	0.001*

^*p < 0.05