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. 2021 Dec 24;13:769462. doi: 10.3389/fnagi.2021.769462

Table 2.

Main results of reviewed articles.

Article Main results
Åhman et al. (2020a) The following variables showed significant association with incidence of dementia in the general sample:
- Naming animals DT time (s)
- Numbers of words recited in naming animals DT (n)
- Words recited per 10 s during the naming animals DT (n)
- Counting backward DT time (s)
- Number of words recited in the reciting months backward DT (n)
- Words recited per 10 s during the reciting months backward DT (n) The following variables were strongly associated with the incidence of dementia in younger than 72 years subsample:
- Words recited per 10 s during the naming animals DT (n)
Beauchet et al. (2017) Significative association in increased delta MMSE with:
- Mean value of stride time in naming animals DT
- CoV of stride time in naming animals DT
- Delta CoV in naming animas DT
Ceïde et al. (2018) Significative association with the incident and vascular dementia:
- Swing time SD in DT
De Cock et al. (2019) In the general sample, the initial MCI group:
- Step width (cm) in “UPG + counting down from 50 in steps of two” DT differentiated between eventual AD+FTD (Alzheimer's disease and frontotemporal dementia) and non-demented people.
- Gait speed (cm/s), normalized gait speed (m/s) and normalized steps/meter (steps/m) in “UPG + naming animals” DT differentiated between at risk for VascD+LBD (vascular dementia and Lewy Body dementia) and non-demented people. In older than 70 years subsample, the initial MCI group:
- Step width (cm) in “UPG + counting down from 50 in steps of two” DT differentiated between non-demented and eventual AD + FTD.
- Gait speed (cm/s), normalized gait speed (m/s) and normalized steps/meter (steps/m) differentiated between VascD + LBD and non-demented people.
Deshpande et al. (2009) There was no significant association between DT variables and cognitive decline.
Donoghue et al. (2018) There was no significant association between DT variables and cognitive decline.
Gillain et al. (2016) Significative differences between demented MCI group and non-demented group in:
- Gait speed (m/s)
- Symmetry (absolute value)
Montero-Odasso et al. (2017) Significative association between dementia progression and:
- Counting backward from 100 DT gait speed (cm/s, continuous variable)
- Naming animals DT gait speed (cm/s, continuous variable)
- Naming animals DT gait speed cost (%, continuous variable)
Muurling et al. (2020) There was no significant association between DT variables and cognitive decline
Nielsen et al. (2018) There was no significant association between DT variables and cognitive decline
Osuka et al. (2020a) Significative association between cognitive decline and the highest tertile of S-TMT time (s)
Rosso et al. (2019) Significative association between cognitive decline progression and:
- DT gait speed percent change (%)
- DT gait speed (0.1 m/s)

This table summarizes the results of the 12 analyzed prospective studies regarding dual-task prediction. DT, dual-task; TUG, Timed up and Go test; UPG, Usual pace gait; CoV, Coefficient of variation; S-TMT, Stepping Trail Making Test (consisting of a test where the participant is asked to walk inside a 1 × 1 m square divided into 16 squares of the same size numbered from 1 to 16 in an established order, stepping the squares in consecutive order) (Osuka et al., 2020b). MMSE, MiniMental State Scale; MCI, Mild Cognitive Impairment; SCI, Subjective cognitive impairment; AD, Alzheimer's disease. DT cost was calculated from the formula: [(usual pace gait parameter – gait parameter)/usual pace gait parameter] × 100. CoV = [(standard deviation/mean) × 100]. Delta mean value, and delta CoV were calculated from the formula: [dual-task–single task/(dual-task + single task)/2] × 100. Delta MMSE was calculated from the formula: [baseline MMSE–MMSE at 5 years of follow-up/(baseline MMSE + MMSE at 5 years of follow-up)/2] × 100.