Skip to main content
. 2021 Dec 24;8:752404. doi: 10.3389/fmolb.2021.752404

FIGURE 5.

FIGURE 5

Metabolic gene expression higher in glioblastoma (GBM) patients than in LGG patients. (A) Higher glycolytic gene expression in glioblastoma (GBM) patients compared with lower grade glioma (LGG) patients. Red RL indicates association with a rate limiting step of glycolysis. (B) Higher relative gene expression of TCA cycle genes in glioblastoma (GBM) patients compared with lower grade glioma (LGG) patients.(C) Higher relative gene expression of PPP genes in glioblastoma patients compared with lower grade glioma (LGG) patients.(D) Higher relative gene expression of oxidative phosphorylation (OXPHOS) genes expression in glioblastoma (GBM) patients compared with lower grade glioma (LGG) patients. Gene expression data from The Cancer Genome Atlas (TCGA) including TCGA-LGG and TCGA-GBM (GSE83130) downloaded from the cBioPortal for Cancer Genomics. Relative RNA Seq V2 RSEM normalized gene expression was used for analysis. Significance calculated via Mann-Whitney U Test. LGG n = 530, GBM n = 152 **** indicates p < 0.0001.