Table 2.
Fixed amino acid substitutions predicted to affect protein function. Scores of deleterious effects of replacing D. p. pseudoobscura with the D. p. bogotana amino acids
| Gene | Substitution | Polyphen-2 | Provean |
|---|---|---|---|
| GA19787 | S310N | 0.375 | −0.053 |
| Q544L | 0.001 | −0.291 | |
| Ovd | M4I | 0.009 | −1.404 |
| R24K | 0.574 | −1.763 | |
| T47S | 0.991 | −1.667 | |
| A72S | 0.574 | −0.158 | |
| A127P | 0.010 | 0.426 | |
| L186V | 0.991 | −1.632 | |
| K190N | 0.001 | 2.561 | |
| GA15499 | G231R | N/A | 0.224 |
| GA14860 | K528R | 0.007 | −0.339 |
| GA14176 | A502V | 0.012 | 0.193 |
Underlined are scores for amino acid substitutions predicted as damaging protein function. Bold are amino acid changes within the DNA/RNA binding domain