TABLE 1.
Top 24 enriched diseases of 44 HP-MRGs analyzed with the Comparative Toxicogenomics Database.
| Disease name | Disease categories | p-value | Corrected p-value | Annotated genes quantity | Annotated genes | Genome frequency |
|---|---|---|---|---|---|---|
| Metabolism, inborn errors | Genetic disease (inborn)|metabolic disease | 3.37E-12 | 1.09E-09 | 12 | AGPAT2|APRT|ASS1|GSS|IDH2|ITPA|LDHB|OGDH|OPLAH|PC|PDHB|PMM2 | 706/44146 genes: 1.60% |
| Nutritional and metabolic diseases | 3.17E-11 | 1.02E-08 | 15 | AGPAT2|APRT|ASS1|CA3|ENTPD6|GSS|IDH2|ITPA|LDHB|OGDH|OPLAH|PC|PDHB|PIK3CA|PMM2 | 1656/44146 genes: 3.75% | |
| Pathological conditions, signs, and symptoms | 1.4E-09 | 4.53E-07 | 18 | AKR1B1|ALOX15|BDH1|BLVRA|CA3|CANT1|DGKZ|ENTPD2|ENTPD6|GMPPA|GPX2|IDH2|ITPA|LDHB|PAFAH1B1|PC|PIK3CA|PMM2 | 3421/44146 genes: 7.75% | |
| Metabolic diseases | Metabolic disease | 2.04E-09 | 6.59E-07 | 13 | AGPAT2|APRT|ASS1|GSS|IDH2|ITPA|LDHB|OGDH|OPLAH|PC|PDHB|PIK3CA|PMM2 | 1540/44146 genes: 3.49% |
| Genetic diseases, inborn | Genetic disease (inborn) | 2.55E-09 | 8.22E-07 | 15 | AGPAT2|APRT|ASS1|CANT1|GMPPA|GSS|IDH2|ITPA|LDHB|OGDH|OPLAH|PC|PDHB|PIK3CA|PMM2 | 2275/44146 genes: 5.15% |
| Congenital, hereditary, and neonatal diseases and abnormalities | 8.69E-09 | 2.81E-06 | 16 | AGPAT2|APRT|ASS1|CANT1|GMPPA|GSS|IDH2|ITPA|LDHB|OGDH|OPLAH|PAFAH1B1|PC|PDHB|PIK3CA|PMM2 | 2912/44146 genes: 6.60% | |
| Pathologic processes | Pathology (process) | 3.42E-08 | 1.11E-05 | 14 | AKR1B1|BDH1|BLVRA|CA3|CANT1|DGKZ|ENTPD2|GPX2|IDH2|ITPA|LDHB|PAFAH1B1|PC|PIK3CA | 2342/44146 genes: 5.31% |
| Digestive system diseases | Digestive system disease | 3.99E-08 | 1.29E-05 | 15 | AKR1B1|ALOX15|ASS1|BDH1|BLVRA|CA3|DGAT2|ENTPD2|GMPPA|GPX2|LDHB|OGDH|PC|PIK3CA|PMM2 | 2793/44146 genes: 6.33% |
| Liver diseases | Digestive system disease | 3.25E-07 | 0.000105 | 12 | AKR1B1|ASS1|BDH1|BLVRA|CA3|DGAT2|ENTPD2|GPX2|LDHB|OGDH|PC|PIK3CA | 1964/44146 genes: 4.45% |
| Neoplasms | Cancer | 1.7E-06 | 0.00055 | 15 | AKR1B1|ALOX15|APRT|DEGS1|ENTPD6|GPX2|GSS|IDH2|LDHB|PAFAH1B1|PC|PDHB|PIK3CA|PMM2|PYGB | 3736/44146 genes: 8.46% |
| Carcinoma, renal cell | Cancer|urogenital disease (female)|urogenital disease (male) | 9.17E-06 | 0.00296 | 4 | APRT|LDHB|PDHB|PIK3CA | 131/44146 genes: 0.30% |
| Amino acid metabolism, inborn errors | Genetic disease (inborn)|metabolic disease | 1.33E-05 | 0.0043 | 4 | ASS1|GSS|OGDH|OPLAH | 144/44146 genes: 0.33% |
| Liver cirrhosis | Digestive system disease|pathology (process) | 2.74E-05 | 0.00885 | 7 | AKR1B1|BDH1|BLVRA|CA3|ENTPD2|LDHB|PC | 895/44146 genes: 2.03% |
| Kidney neoplasms | Cancer|urogenital disease (female)|urogenital disease (male) | 4.11E-05 | 0.01327 | 4 | APRT|LDHB|PDHB|PIK3CA | 192/44146 genes: 0.43% |
| Fibrosis | Pathology (process) | 4.19E-05 | 0.01354 | 7 | AKR1B1|BDH1|BLVRA|CA3|ENTPD2|LDHB|PC | 957/44146 genes: 2.17% |
| Brain diseases, metabolic, inborn | Genetic disease (inborn)|metabolic disease|nervous system disease | 0.000052 | 0.0168 | 4 | ASS1|IDH2|PC|PDHB | 204/44146 genes: 0.46% |
| Chemical and drug-induced liver injury | Digestive system disease | 5.44E-05 | 0.01756 | 5 | BDH1|CA3|DGAT2|OGDH|PC | 410/44146 genes: 0.93% |
| Kidney diseases | Urogenital disease (female)|urogenital disease (male) | 5.98E-05 | 0.01931 | 6 | APRT|DGKH|IDH2|LDHB|PDHB|PIK3CA | 688/44146 genes: 1.56% |
| Brain diseases, metabolic | Metabolic disease|nervous system disease | 9.14E-05 | 0.02951 | 4 | ASS1|IDH2|PC|PDHB | 236/44146 genes: 0.53% |
| Diabetes complications | Endocrine system disease | 0.000109 | 0.03522 | 3 | AKR1B1|ASS1|DGKH | 92/44146 genes: 0.21% |
| Pyruvate metabolism, inborn errors | Genetic disease (inborn)|metabolic disease | 0.000115 | 0.0373 | 2 | PC|PDHB | 16/44146 genes: 0.04% |
| Liver cirrhosis, experimental | Digestive system disease|pathology (process) | 0.000116 | 0.03761 | 6 | AKR1B1|BDH1|BLVRA|CA3|LDHB|PC | 777/44146 genes: 1.76% |
| Neoplasms by site | Cancer | 0.000117 | 0.03763 | 11 | AKR1B1|ALOX15|APRT|DEGS1|GPX2|GSS|LDHB|PDHB|PIK3CA|PMM2|PYGB | 2958/44146 genes: 6.70% |
| Neoplastic processes | Cancer|pathology (process) | 0.000133 | 0.04289 | 5 | GPX2|IDH2|LDHB|PAFAH1B1|PIK3CA | 496/44146 genes: 1.12% |
HP-MRGs: Helicobacter pylori–associated metabolism-related genes.