TABLE 2.
The composition, molar ratio and API solubility of DESs as new solvents for APIs.
| DES composition | Molar ratio | API | Solubility (mg/ml) | References | |
|---|---|---|---|---|---|
| Choline chloride | Glycolic acid | 1:2 | Itraconazole | 6.70 | Li et al. (2016) |
| Piroxicam | 9.90 | ||||
| lidocaine | 100.60 | ||||
| Posaconazole | 76.80 | ||||
| Glycolic acid: Oxalic acid | 1:1.7:0.3 | Itraconazole | 46.40 | Li et al. (2016) | |
| Piroxicam | 3.10 | ||||
| lidocaine | 295.40 | ||||
| Posaconazole | 88.40 | ||||
| Benzoic acid | 23.00 | ||||
| Danazol | 0.016 | ||||
| Urea | 1:3 | Griseofulvin | 0.0061 | Morrison et al. (2009) | |
| AMG517 | 0.00022 | ||||
| Itraconazole | <0.001 | ||||
| Benzoic acid | 18.0 | ||||
| Malonic acid | 1:3 | Danazol | 0.1007 | Morrison et al. (2009) | |
| Griseofulvin | 0.0044 | ||||
| AMG517 | 0.014 | ||||
| Itraconazole | 6.60 | ||||
| Glycerol | 1:1 | Curcumin | 7.25 | Jeliński et al. (2019) | |
| Maleic acid | 3:1 | Curcumin | 0.0667 | Wikene et al. (2015) | |
| 1,2-Propanediol | 1:2 | Aspirin | 202.00 | Lu et al. (2016) | |
| acetaminophen | 324.00 | ||||
| Naproxen | 45.26 | ||||
| Levulinic acid | 1:2 | Ketoprofen | 329.10 | Lu et al. (2016) | |
| Proline | Urea | 2:1 | Berberibe | 12.3 | Sut et al. (2017) |
| Malic acid: Lactic acid: Water | 1:0.2:0.3:0.5 | Berberibe | 25.0 | Sut et al. (2017) | |
| Glutamic acid | 2:1 | Rutin | 2.9384 | Faggian et al. (2016) | |
| Choline chloride | 1:3 | Rutin | 2.7992 | Chen et al. (2015) | |
| Others | Borneol:Menthol | 1:3 | Daidzein | 0.00031 | Shen et al. (2011) |
| Glucose:Sucrose | 1:1 | Curcumin | 0.05211 | Wikene et al. (2015) | |
| Choline bicarbonate: Geranic acid | 1:1 | Insulin | -- | Banerjee et al. (2017) | |
| Choline bicarbonate: Geranic acid | 1:1 | BSA | -- | Banerjee et al. (2017) | |
| Camphor:Menthol | 1:1 | Ibuprofen | 282.11 | Myung et al. (2012) | |