TABLE 4.

Pharmacokinetic data summary of preclinical studies of nanoparticles containing UA.

Parameter	Lipo E	Nano A	Nano G	Poli B
Administration route	intragastric	intravenous	intravenous	intravenous
UA dose (mg/kg)	80	10	10	11
${\text{T}}_{1/2}$ (hour)	8.6	8.3 and 10	8.7	4.9 and 5.2
AUC (µg.h/ml)	134.061	NA	NA	NA
${\text{C}}_{\text{max}}$ (µg/ml)	19.87	NA	NA	NA
${\text{T}}_{\text{max}}$ (hour)	NA	80	80	48

Notes: ${\text{T}}_{1/2}$ , half-life time; AUC, area under curve of concentration versus time; ${\text{C}}_{\text{max}}$ , maximum plasma concentration; ${\text{ T}}_{\text{max}}$ , time required to reach maximum plasma concentration.