TABLE 6.

The relative body weight of animal models treated with UA-loaded nanoparticles compared to negative control and native UA-treatment groups.

Code	Toxicity
Lipo H	ALT and AST levels were significantly higher following an injection of FA-UA/siRNA-L compared to that of saline solution. The AST/ALT ratio of the FA-UA/siRNA-L group was significantly lower than that of the saline group. These results suggest that liver toxicity caused by liposomes produces mild, temporary liver toxicity
Nano A	The number of rat WBCs in the NP HCPT@F-Pt-PU treatment group increased more rapidly than in the native UA group which suggests that folate-targeted pectin delivery systems may prevent serious hematological toxicity
Nano D	There was no obvious cell damage or morphological changes in the major organs i.e., heart, liver, spleen, lungs, and kidneys in the NP UA-LA-ICG treatment group members compared to those of the negative control group
Nano E	ALT levels in mice treated with UA-NP were significantly lower than in the CCl4 group members, but there were no changes in the native UA- treatment group. In addition, AST levels in the UA-NP treatment group were also significantly lower compared to the CCl4 group and the native UA-treatment groups
Nano F	The native UA group experienced necropsy in the central section of the tumor tissue. These results partly suggest that native UA causes more toxicity than UA-NP. Meanwhile, H&E staining indicated that there were no obvious abnormalities or inflammatory lesions in any of the five organs, i.e., heart, liver, spleen, lungs, kidneys for the UA-NP treatment group when compared to their negative control and native UA counterparts
Nano G	Rats treated with the Pec-8PUH-NPs group did not experience any significant reduction in WBC counts as an indicator of hematotoxicity suggesting that the use of nanoparticles might prevent hematological toxicity