Table 2.

Remaining teeth at baseline and follow ups, differences at follow ups according to genotypes.

Gene	Genotype	B				FU1			FU2		Delta n teeth median (min–max)
		n	Median min–max	IQR	n	Median min–max	IQR	n	Median min–max	IQR	B-FU1	B-FU2	FU1-FU2
COL1A1
	ss	39	7 0–31	0–14	24	8.5 0–25	0–13.25	15	9 0–25	0–15.5	0# 0–6	0 0–9	0∗ 0–6
	Ss	345	3 0–30	0–14.25	234	1.5 0–30	0–15	161	1 0–22	0–14	2 0–22	3 0–22	1 0–16
	SS	688	2 0–31	0–14	468	0 0–30	0–11	312	1 0–24	0–10	2 0–27	2.5 0–24	0 0–24
VDR
	ff	32	0.5 0–32	0–9.75	18	1.5 0–32	0–12	14	0 0–30	0–11.5	1 0–5	2 0–14	0 0–10
	Ff	133	3 0–30	0–14	84	2 0–30	0–15	59	0 0–28	0–14	1 0–15	3 0–16	0 0–16
	FF	135	5 0–31	0–18	86	4.5 0–30	0–16	50	4 0–29	0–12.75	2 0–27	2 0–20	0 0–11
CALCR
	CC	86	2 0–28	0–13	63	0 0–28	0–8	50	0 0–25	0–8	1 0–10	2 0–21	0 0–21
	CT	536	3 0–31	0–14	380	1 0–30	0–12	284	1 0–31	0–13	1 0–27	2 0–18	0 0–15
	TT	808	3 0–30	0–14	613	1 0–30	0–11	508	1 0–30	0–10	2 0–21	3 0–21	0 0–15
ESR1-Pvu
	pp	382	5 0–29	0–14	281	2 0–29	0–10	212	2 0–29	0–10	2 0–22	3 0–22	0 0–14
	Pp	705	2 0–31	0–13	509	1 0–30	0–11	367	0 0–29	0–10	1 0–22	3 0–21	0 0–21
	PP	248	2 0–31	0–14	182	0 0–28	0–11	130	2 0–28	0–13	1 0–20	2 0–20	0 0–10
ESR1-Xba
	xx	472	4 0–31	0–14.25	351	2 0–30	0–10	252	1 0–29	0–10	2 0–22	3 0–22	0 0–14
	Xx	683	2 0–31	0–13	485	1 0–30	0–11	359	0 0–29	0–11	1 0–22	3 0–21	0 0–21
	XX	179	2 0–28	0–15.5	135	0 0–28	0–10.5	97	1 0–28	0–14	2 0–20	2 0–20	0 0–10

B = baseline; FU = follow up; IQR = interquartile range; genes: CALCR = calcitonin receptor; COL1A = collagen type Iα1; ESR1 = estrogen receptor alpha; VDR = vitamin D receptor.

∗p = 0.017; #p = 0.057.