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Preparation and application of chemically modify DNA strands for RNAs delivery. (A) Schematic illustration of copper-free azide-alkyne click reaction between azide and DBCO. (B) The DNA structures formed by click reaction with controlled architectures, such as dimer, trimer, cross-shape, and 1D polymer DNA frame (Lin et al., 2019). (C) Synthesis route of PDA-coated nucleic acid nanogel. (D) Schematic illustration of endosomal escape and PTT induced by PDA (Ding L. et al., 2020).
