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Mechanism of exosomes in immune escape. (A) CD47 protects exosomes from being cleared by monocytes and macrophages: flow cytometry analysis of AF647-tagged siRNA in exosomes with normal/knockout (KO)/high-expression CD47 in the circulation (Kamerkar et al., 2017). (B) Cltc blocking inhibits the macrophages endocytosis and decreases the accumulation of DiR-loaded exosomes in liver and spleen (C) (Wan et al., 2020).
