TABLE 1.
Vectors | RNA target | Specifics | References | |
---|---|---|---|---|
DNA Assemblies | DNA | Bcl-2 | None | Rahman et al.(2017) |
DNA | Survivin | None | Chen et al. (2015) | |
DNA | VEGF | hairpin structure oligonucleotide for active targeting | Ren et al. (2016) | |
DNA | PLK1 | Aptamer AS1411 for active targeting | Lin et al. (2020) | |
DNA | Braf | Aptamer AS1411 for active targeting | Xiao et al. (2021) | |
DNA | PLK1 | FA for active targeting; influenza hemagglutinin peptide for endosomal escape | Liu et al. (2021a) | |
DNA | Bcl-2 | DOX for combination therapy; TAT for cell-penetrating | Wang et al. (2021a) | |
P-gp | ||||
DNA + Spermidine | mTOR | None | Wang et al. (2018a) | |
DNA-PCL | PLK1 | None | Ding et al. (2018) | |
DNA-PCL | Hsp70 | PDA for photothermal convertible agent | Ding et al. (2020a) | |
DNA-PCL | EGFP | None | Xue et al. (2019) | |
RNA Assemblies | RNA + amino-modified CD | EpCAM | EpCAM aptamer for active targeting; sorafenib for combination therapy | Chen et al. (2020a) |
RNA | miR205, miR221 | LXL-DNA aptamer for active targeting | Ding et al. (2020b) | |
RNA + PEI | Bcl-2 | DOX for combination therapy | Juneja et al. (2020) | |
pRNA (3WJ) | MED1 | HER2 aptamer for active trageting | Zhang et al. (2017) | |
pRNA (3WJ) | XBP1 | EGFR aptamer for active targeting | Zhang et al. (2021) | |
pRNA (3WJ) | miR21 | FA for active targeting | Lee et al. (2017) | |
pRNA (3WJ)- cholesterol | miR21 | FA for active targeting | Yin et al. (2019) | |
pRNA (3WJ)- cholesterol | Survivin | PSMA and FA for active targeting, exosome for endosome escape | Pi et al. (2017) | |
pRNA (3WJ)- cholesterol | Survivin | FA for active targeting, exosome for endosome escape | Zheng et al. (2019) | |
pRNA (6WJ) | miR122 | PTX for combination therapy, HTL for active targeting | Wang et al. (2021b) |
Bcl-2: B-cell lymphoma-2; mTOR: mammalian target of rapamycin; VEGF: vascular endothelial growth factor; PLK1: polo-like kinase 1; P-gp: P-glycoprotein; Hsp70: heat-shock-protein 70; EGFP: enhanced green fluorescent protein; EpCAM: epithelial cell adhesion molecule; MED1: Mediator Subunit 1; XBP1: X-box-binding protein 1; HTL: hepatocyte targeting ligand; HER2: human epidermal growth factor receptor-2; EGFR: epidermal Growth Factor Receptor PSMA: prostate-specific membrane antigen.