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. 2021 Dec 24;12:734443. doi: 10.3389/fphar.2021.734443

TABLE 1.

Oligonucleotides-based nano-sysetems for RNA delivery.

Vectors RNA target Specifics References
DNA Assemblies DNA Bcl-2 None Rahman et al.(2017)
DNA Survivin None Chen et al. (2015)
DNA VEGF hairpin structure oligonucleotide for active targeting Ren et al. (2016)
DNA PLK1 Aptamer AS1411 for active targeting Lin et al. (2020)
DNA Braf Aptamer AS1411 for active targeting Xiao et al. (2021)
DNA PLK1 FA for active targeting; influenza hemagglutinin peptide for endosomal escape Liu et al. (2021a)
DNA Bcl-2 DOX for combination therapy; TAT for cell-penetrating Wang et al. (2021a)
P-gp
DNA + Spermidine mTOR None Wang et al. (2018a)
DNA-PCL PLK1 None Ding et al. (2018)
DNA-PCL Hsp70 PDA for photothermal convertible agent Ding et al. (2020a)
DNA-PCL EGFP None Xue et al. (2019)
RNA Assemblies RNA + amino-modified CD EpCAM EpCAM aptamer for active targeting; sorafenib for combination therapy Chen et al. (2020a)
RNA miR205, miR221 LXL-DNA aptamer for active targeting Ding et al. (2020b)
RNA + PEI Bcl-2 DOX for combination therapy Juneja et al. (2020)
pRNA (3WJ) MED1 HER2 aptamer for active trageting Zhang et al. (2017)
pRNA (3WJ) XBP1 EGFR aptamer for active targeting Zhang et al. (2021)
pRNA (3WJ) miR21 FA for active targeting Lee et al. (2017)
pRNA (3WJ)- cholesterol miR21 FA for active targeting Yin et al. (2019)
pRNA (3WJ)- cholesterol Survivin PSMA and FA for active targeting, exosome for endosome escape Pi et al. (2017)
pRNA (3WJ)- cholesterol Survivin FA for active targeting, exosome for endosome escape Zheng et al. (2019)
pRNA (6WJ) miR122 PTX for combination therapy, HTL for active targeting Wang et al. (2021b)

Bcl-2: B-cell lymphoma-2; mTOR: mammalian target of rapamycin; VEGF: vascular endothelial growth factor; PLK1: polo-like kinase 1; P-gp: P-glycoprotein; Hsp70: heat-shock-protein 70; EGFP: enhanced green fluorescent protein; EpCAM: epithelial cell adhesion molecule; MED1: Mediator Subunit 1; XBP1: X-box-binding protein 1; HTL: hepatocyte targeting ligand; HER2: human epidermal growth factor receptor-2; EGFR: epidermal Growth Factor Receptor PSMA: prostate-specific membrane antigen.