TABLE 3.

Cell membranes-based nano-systems for RNA delivery.

Cell source	Loading method	RNA target	RNA complex	Specifics	Ref
H1299 cells	Extrusion	PLK1	RNA/PBAE complex	PBAE with pH sensitivity	Zhang et al. (2020b)
HeLa cells	Extrusion	E7	RNA/PEI complex- loaded PLGA NPs	PTX for combination therapy	Xu et al. (2020)
HeLa cells	Sonication	Ca2+ channel	RNA/CS complex	DOX for combination therapy	Zhao et al. (2020)
4T1 cells	Extrusion	Bcl-2	RNA/PAMAM-CD	SN-38 for combination therapy	Fei et al. (2020)
RBC	Extrusion	Survivin	RNA/cationic BSA	RGD for active targeting	Wang et al. (2018b)
RBC	Extrusion	IL-1α	RNA/poly-L-histidine-grafted black phosphorus	PTX for combination therapy	Ou et al. (2019)
RBC	Extrusion	PLK1	RNA/citraconic anhydride grafted PLL	Angiopep 2 peptide for active targeting	Liu et al. (2020)
RBC	Extrusion	P-gp	RNA-cholesterol	DOX for combination therapy; aptamer AS1411 for active targeting	Wang et al. (2019)
Platelet	Extrusion	Survivin	RNA-loaded MOF	MOF with pH sensitivity	Zhuang et al. (2020)
ER	Ultrasound	EGFR	RNA/cationic lipid vesicle	None	Qiu et al. (2019)
Leukocyte	Sonication	LPCAT1	RNA/PEI/lipid vesicle	DOX for combination therapy	Jun et al. (2020)
PCa cells and BMSCs	Ultrasound	SREBP1	RNA/cross-linked peptide-lipoic acid micelle	DTX for combination therapy	Chen et al. (2020a)

IL-1α: Interleukin-1α; LPCAT1: lysophosphatidylcholine Acyltransferase 1; SREBP1: sterol regulatory element-binding protein 1