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. 2021 Dec 24;12:809541. doi: 10.3389/fphar.2021.809541

FIGURE 2.

FIGURE 2

Fluoxetine and vortioxetine decrease the expression of iNOS and Nox2 proteins. Effects induced by i.c.v. administration of Aβ oligomers (Aβ + VEH) in absence or presence of FLX10, VTX5, or VTX10 on (B) iNOS and (D) Nox2 protein levels measured by WB. (A, C) show the representative immunoblots of iNOS (120–125 kDa) and Nox2 (55 kDa), respectively, in total protein extracts from hippocampal tissue. Histograms refer to the means ± S.E.M. of the densitometric values of iNOS or Nox2 bands normalized against β-actin (42 kDa). Each experiment was repeated three times. *p < 0.05 vs. PBS + VEH, # p < 0.05 vs. Aβ oligomers + VEH. ## p < 0.01 vs. Aβ oligomers + VEH, ### p < 0.001 vs. Aβ oligomers + VEH.