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. 2021 Dec 24;12:809541. doi: 10.3389/fphar.2021.809541

FIGURE 4.

FIGURE 4

Fluoxetine and vortioxetine exert neuroprotection against the toxicity induced by Aβ oligomers. Primary mixed neuronal cultures were treated with Aβ oligomers (2 µM) for 48 h both in absence or presence of FLX (1 µM) or increasing concentrations of VTX (100 nM, 250 nM, and 1 µM) (pre-treatment of 1 h). The toxicity of Aβ oligomers in mixed neuronal cultures was assessed by cell counting after trypan blue staining. Cell counts was performed in three random microscopic fields/well. Data are the mean of three to four determinations. S.D. are represented by vertical bars. *p < 0.05 vs. CTRL, **p < 0.01 vs. CTRL, ***p < 0.001 vs. CTRL, # p < 0.05 vs. Aβ, ## p < 0.01 vs. Aβ, ### p < 0.001 vs. Aβ, ՓՓ p < 0.01 vs. VTX 100 nM.