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. 2021 Dec 24;12:727756. doi: 10.3389/fphar.2021.727756

TABLE 3.

Comparison of venom toxin families of Naja samarensis and Naja philippinensis.

Toxin families Naja samarensis Naja philippinensis a
Localities Southern Philippines Northern Philippines
Venom source Pooled sample (5 adults) b Pooled sample (6 adults) c
Fractionation method Reverse-phase HPLC Reverse-phase HPLC
Toxin identification method Nano-ESI-LCMS/MS Nano-ESI-LCMS/MS
Toxin family abundance (%)
3FTx 90.48 66.64
 SαNTX 65.87 44.55
 LαNTX ND ND
 CTX 16.29 21.31
 MTLP 3.86 0.77
 WTX 4.46 0.01
PLA2 3.76 22.88
SVMP 4.17 3.93
CRiSP 1.06 1.49
LAAO 0.26 0.42
NGF 0.13 0.06
VES 0.13 0.05
CVF ND 2.38
5′NUC ND 0.55
PDE ND 0.45
SVSP ND 0.35
a

Referenced from Tan et al. (2019b).

b

Wild caught.

c

Supplied by Latoxan Venom Supply, Valence, France.

Abbreviations: 3FTx, Three-finger toxin; 5′NUC, 5′ nucleotidase; CRiSP, cysteine-rich secretory protein; CTX, cytotoxin; CVF, cobra venom factor; HPLC, high-performance liquid chromatography; LAAO, L-amino acid oxidase; LαNTX, long-chain alpha-neurotoxin; MTLP, muscarinic toxin-like protein; ND, not detected; NGF, nerve growth factor; PDE, phosphodiesterase; PLA2, phospholipase A2; SαNTX, short-chain alpha-neurotoxin; SVMP, snake venom metalloproteinases; SVSP, snake venom serine protease; VES, vespryn; WTX, weak toxin.