TABLE 4.

Neutralization of the alpha-neurotoxins and venoms of Philippine cobras, Naja samarensis and Naja philippinensis by antivenom.

		LD50 (μg/g)	Challenge dose	PCAV (16.2 ± 1.1 mg/ml)
				ED50 (μl)	ER50 (mg/ml)	P (mg/ml)	Normalized P (mg/g)
Alpha-neurotoxins	NS-SαNTX	0.18 (0.12–0.29)	5 LD50	91.24 (58.29–142.80)	0.25 (0.16–0.40)	0.20	12.18
	NP-SαNTX	0.10 (0.06–0.15)	5 LD50	44.94 (29.60–68.23)	0.28 (0.17–0.42)	0.22	13.74
Venom	Naja samarensis*	0.20 (0.16–0.25)	5 LD50	120.86 (104.79–139.40)	0.21 (0.17–0.26)	0.17	10.21
	Naja philippinensis #	0.18 (0.12–0.27)	5 LD50	44.94 (29.60–68.23)	0.50 (0.33–0.75)	0.40	24.72

LD₅₀ (Lethal dose): Venom dose (µg/g) at which 50% of the mice were dead.

ED₅₀ (Median effective dose): Antivenom dose (μl) at which 50% of tested mice survived.

ER₅₀ (Median effective ratio): Antivenom dose (mg/ml) corresponding to ED₅₀.

P: Potency of antivenom (mg venom neutralized per ml antivenom).

Normalized P: Potency of antivenom (mg venom neutralized per g antivenom).

Abbreviations: NP-SαNTX, Naja philippinensis short-chain alpha-neurotoxin; NS-SαNTX, Naja samarensis short-chain alpha-neurotoxin; PCAV, Philippine Cobra Antivenom.

^# Tan et al., 2019a; (Tan C. H. et al., 2019b).

*Tan et al., 2021; (Tan et al., 2021).