TABLE 2.
Summary of miRNAs involved in the pathogenesis of DCM.
| Mechanism | miRNAs | Regulated genes | Species | Reference |
|---|---|---|---|---|
| Hypertrophy | ↓miR-1 | MEF2a/Gata4 | HG-treated NRCMs and diabetic rats | Ikeda et al. (2009) |
| ↓miRNA-146a | DLST | HG-treated NRCMs | Heggermont et al. (2017) | |
| ↓miR-133a | SCK1/IGF1R | STZ-induced diabetic mice | Feng et al. (2010) | |
| ↓miR-150 | p300 | Diabetic rats | Duan et al. (2013) | |
| ↑miR-200c | DUSP-1 | HG and STZ-induced diabetic rats | Singh et al. (2017) | |
| Fibrosis | ↓miR-152-3p | Wnt1/β-catenin | HG-treated NRCMs | Xu et al. (2021) |
| ↑miR-26a/b-5p | GAS5 | STZ-induced diabetes model | Zhu et al. (2021a) | |
| ↓miR-29b-3p | circHIPK3 | STZ-induced diabetes model | Wang et al. (2021) | |
| ↓miR-223 | NLRP3 | HG-induced cardiomyocyte injury mode | Xu et al. (2020) | |
| ↓miR-155 | TGF-β1 | STZ-induced diabetes model | Zhang et al. (2016) | |
| ↓miR-21 | DUSP8 | HG-induced diabetes model | Liu et al. (2014a) | |
| Apoptosis | ↑miR-133a | caspase-3, caspase-8 | Type 2 diabetic rats | Habibi et al. (2020) |
| ↑miR-181a-5p | JAK2/STAT3 | Human cardiomyocytes | Tan et al. (2021) | |
| ↑miR-146a | MAPK | H9C2 cells | Chu et al. (2021) | |
| ↑miR-140-5p | HDAC4/Neat1 | STZ-induced diabetic mice | Zou et al. (2019) | |
| ↓miR-1 | IGF1 | Diabetic rats | Delfan et al. (2020) | |
| ↓miR-675 | VDAC1 | STZ-induced diabetic rats | Li et al. (2016b) | |
| Autophagy | ↑miR-221-3p | GAS5 | STZ-induced diabetic rats and HG treated H9C2 | Chen and Zhang, (2021) |
| ↑miR-551b-5p | DCRF | STZ-induced diabetic rats | Feng et al. (2019) | |
| ↑miR-34a | Bcl2 and Sirt1 | HG treated H9C2 | Zhu et al. (2019) | |
| - | STZ-induced diabetic mice and HG- induced cardiomyocytes | Ni et al. (2020) | ||
| Oxidative stress | ↓miR-128 | PIK3R1/Akt/mTOR | C57 BL/6 mice | Zhan et al. (2021) |
| ↓MiR-22 | Sirt1 | HFD and STZ-induced diabetic mice | Tang et al. (2018) | |
| ↓miR-1 and ↓miR-499 | RyR2 | Diabetic rats | Yildirim et al. (2013) | |
| ↓miR-150 | P300 | Diabetic rats | Duan et al. (2013) | |
| Inflammation | ↓miR-130 | PPAR-γ | H9C2 cells | Chu et al. (2018) |
| ↑miR-150-5p | Smad7 | HG- induced diabetes model | Che et al. (2020) | |
| ↓miR146a | IL6, TNFα, IL-1β, MCP-1 | Human cardiac microvascular endothelial cells and STZ-induced diabetes | Feng et al. (2017) | |
| ↓miR-214-3p | KCNQ1 | STZ-induced diabetes model and cardiomyocytes treated with HG | Yang et al. (2018) | |
| ↓miR-675 | VDAC1 | STZ induced diabetic rats | Li et al. (2016b) |
NRCMs, neonatal rat cardiomyocytes; HFD, high fat diet; HG, high glucose ; STZ, streptozotocin.