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. 2021 Dec 24;11:765842. doi: 10.3389/fcimb.2021.765842

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Copyright © 2021 Ray, Luis, Mishra, Barry, Asim, Pandey, Chaturvedi, Gupta, Gupta, Mahant, Das, Kumar, Shalimar, Wilson, Schneider and Chaturvedi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H. pylori output strains isolated from dietary curcumin-treated mice induce attenuated host response. (A) Western blot analysis of cSrc phosphorylation in AGS cells treated with H. pylori isolated from mice fed control chow (vehicle) or chow containing 1% Meriva. H. pylori-infected mice fed with chow containing 1% Meriva for 4 weeks shows attenuation of phosphorylation of c-Src. (B) Quantification of p-Src/cSrc in the Western blot samples in (A) showing attenuation. (C) Quantification of CXCL8 mRNA when co-cultured with AGS cells showing reduced level. (D) CFU per gram of tissue showing no colonization. ***P ≤ 0.001, ^§§§P ≤ 0.001.