Table 4.

Changes in metabolites associated with steroid hormone metabolism in serum of the Placebo and the 600mg TT groups at 0 and 12 wk.

Sub pathway	Biochemical name	Placebo: Ratio 12 wk/0 wk	600mg TT: Ratio 12 wk/0 wk
Sterol	Cholesterol	0.93‡	1.08‡
	Beta-sitosterol	0.97	1.25*
Steroid	Pregnenolone sulfate	0.76*	0.94
	5alpha-pregnan-3beta, 20beta-diol monosulfate (1)	0.97	0.83*
	5alpha-pregnan-3beta, 20alpha-diol disulfate	0.93	0.68*
	Pregnen-diol disulfate*	0.92	0.81*
	Pregn steroid monosulfate*	0.85*	0.98
	Dehydroisoandrosterone sulfate (DHEA-S)	0.88*	1.01
	Androsterone sulfate	0.88‡	0.82*
	Androstenediol (3alpha, 17alpha) monosulfate (3)	0.82*	0.82*
	Androstenediol (3beta,17beta) disulfate (1)	0.98	0.89*
	Androstenediol (3beta,17beta) disulfate (2)	0.93	0.85‡
	5alpha-androstan-3alpha, 17beta-diol monosulfate (1)	0.99	0.80*
	5alpha-androstan-3beta, 17beta-diol monosulfate (2)	1.05	0.76*
	5alpha-androstan-3beta,17alpha-diol disulfate	0.89	0.60*
	5alpha-androstan-3alpha,17beta-diol disulfate	0.88	0.60*
	5alpha-androstan-3beta, 17beta-diol disulfate	1.02	0.67*

Metabolite values are expressed as the ratio of Placebo 12 wk/0 wk which is the fold change of the Placebo at 12 wk compared to the Placebo at 0 wk. Similarly, the ratio of 600mg TT 12 wk/0 wk which is the fold change of the 600mg TT at 12 wk compared to the 600mg TT at 0 week. A ratio >1 indicates a value larger for the 12-wk collection (Placebo 12 wk or 600mg TT 12 wk) and <1 the value for the 12-wk collection (Placebo 12 wk or 600mg TT 12 wk) is lower compared to the 0-wk collection (Placebo 0 wk or High TT 0 wk). Statistical differences are indicated for the values at baseline and after 12 weeks within the same treatment group or placebo (n = 20).

^*Indicates p < 0.05.

^‡Indicates 0.05 < p < 0.1.