Fig. 1.

Difference in DNA methylation profiles between CNE-2 cell and CNE-2R cells. (A) Hierarchical clustering heatmap showing DNA methylation status in the three groups. (B) In the volcano plot, the two vertical lines are the PeakDMvalue = 0.2 change boundaries, and the horizontal line is the statistical significance boundary (PeakScore –log10 (P value) ≥2). Compared with the CNE-2 group, items in the CNE-2R group with statistical significance as well as hypermethylation are presented as red dots, and hypomethylation is presented as blue dots. (C) KEGG pathway analysis of the differentially expressed genes showing the top 10 categories (ranked by enrichment score). (D) Corresponding gene enrichment using DAVID analysis showing the top 10 items for each term (ranked using enrichment score). SMY: Shengmai Yin; GO: gene ontology.