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. 2022 Jan 6;15:10. doi: 10.1186/s13041-021-00896-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effect of optical suppression of D2-receptor-expressing neurons in the NAc on neuropathic pain. a Schematic showing that AAV-Flex-ArchT-GFP was microinjected into the NAc of D2-cre mice. b Experimental timeline. c Examples of biocytin-stained ArchT-GFP-expressing neurons in a D2R-cre mouse (upper) and representative current-clamp trace from a NAc neuron expressing ArchT showing reliable suppression of the firing of neurons during photostimulation (orange line) (lower). d-f Effects of optical suppression of D2-receptor-expressing neurons in the NAcMed, NAcLat and NAcCo in mice. Latency in the response to thermal stimulation under a neuropathic pain-like state by optical stimulation of the NAcMed (d), NAcLat (e) and NAcCo (f) in Wild-type/ArchT and D2-cre/ArchT mice. Data are presented as the mean ± SEM of 5-6 animals. ^***p < 0.001 vs. Wild-type/ArchT ligation contralateral paw; ^###p < 0.001 vs. D2-cre/ArchT ligation contralateral paw; ^$$$p < 0.001 vs. Wild-type/ArchT ligation ipsilateral paw