Table 3.

Univariable and multivariable cox proportional hazard regression models for overall survival in CHAARTED high-volume group

	Univariable			Multivariable
	HR	95% CI	P value	HR	95% CI	P value
Age (≥73)	1.79	1.27–2.54	0.0009	1.55	0.98–2.51	0.0636
initial PSA (≥485)	0.92	0.65–1.29	0.6248	-	-	-
GS ≥ 9	1.66	1.11–2.54	0.0127	1.47	0.87–2.59	0.1499
T stage (≥T3b)	1.75	1.12–2.90	0.0137	1.14	0.63–2.21	0.6755
N stage (positive)	2.00	1.35–3.04	0.0004	1.66	0.99–2.90	0.0555
Hb (<13.3)	1.4	0.99–2.01	0.0575	-	-	-
LDH (≥ 205)	2.31	1.61–3.35	< 0.0001	2.63	1.62–4.36	< 0.0001
ALP (≥352)	1.61	1.11–2.39	0.0118	1.52	0.93–2.54	0.1003
NLR (≥2.6)	0.77	0.54–1.11	0.1641	-	-	-
CRP (≥ 0.19)	2.06	1.32–3.29	0.0013	1.65	1.02–2.73	0.0420

ALP, alkaline phosphatase; CI, confidence interval; CRP, C-reactive protein; GS, Gleason score sum; Hb, haemoglobin; HR, hazard ratio; LDH, lactate dehydrogenase; NLR, neutrophil-lymphocyte ratio; PSA, prostate-specific antigen.