(A) The content of heart enzyme creatine kinase-muscle brain (CK-MB) in rat plasma (n=5. The original data are shown in Table S9). (B) Histopathological examination of the myocardium (blue arrows: cardiomyocyte necrosis, muscle fibre rupture, and myofibrillar dissolution; black arrows: the space of cardiac muscle was widened; yellow arrows: infiltration of inflammatory cell). (C) Score of lesion grade in each rat group (score 1: no obvious lesions; black score 2: slight lesions; score 3: mild lesions; score 4: moderate lesions; score 5: severe lesions; n=5). (D) The content of metabolites in the energy metabolism pathway in rat myocardium (n=5. The original data are shown in Table S10). (E) The protein expression levels of PDH, CS, SUCLG, and SDH in rat myocardium (n=4–10. The original data are shown in Figs. S8–S12). Error bars represent mean ± SD, #P < 0.05, ##P < 0.01. PDHA and PDHX are subunits of PDH. SUCLG1 is a subunit of SUCLG. SDHB is a subunit of SDH.