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. 2022 Jan 5;24(2):155–164. doi: 10.1016/j.neo.2021.12.008

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© 2021 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 3 — Enrichment plots of the four gene sets of the hallmark pathways that are enriched in ovarian cancer versus controls (adjusted p-value < 0.05). (A) Enrichment plot for genes encoding cell cycle related targets of E2F transcription factors (NES = 2.34, padj = 0.02). (B) Enrichment plot for genes involved in the G2/M checkpoint, as in progression through the cell division cycle (NES = 2.25, padj = 0.02). (C) Enrichment plot for genes upregulated by activation of hedgehog signaling (NES = 1.85, padj = 0.03). (D) Enrichment plot for genes important for mitotic spindle assembly (NES = 1.71, padj = 0.02). NES, normalized enrichment score; padj, adjusted p-value.