Table 5.
The association between inflammatory marker hCRP and lipid profiles and cardiovascular risk parameters and clinic characteristics of patients with psoriasis
| Predictors | Univariate analysis | Stepwise regression analysis | |||||
|---|---|---|---|---|---|---|---|
| p-value | B | 95% CI for B | p-value | B | 95% CI for B | ||
| hCRP | PASI score at baseline | .000 | 0.142 | (0.084–0.200) | .000 | 0.144 | (0.083–0.205) |
| BMI | .001 | 0.203 | (0.079–0.328) | .003 | 0.195 | (0.065–0.324) | |
| ApoB/ApoA1 | .000 | 4.009 | (1.777–6.241) | .011 | 3.153 | (0.746–5.56) | |
| Smoking | .022 | 0.821 | (0.119–1.522) | .015 | 0.841 | (0.165–1.518) | |
| ApoA1 | Sex | .000 | −0.128 | (−0.129 to −0.086) | .001 | −0.091 | (−0.142 to −0.039) |
| Age | .000 | 0.003 | (0.002–0.004) | .006 | 0.002 | (0.001–0.004) | |
| Weight | .000 | −0.005 | (−0.006 to −0.003) | .004 | −0.003 | (−0.005 to −0.001) | |
| hCRP | .003 | −0.012 | (−0.02 to −0.004) | .006 | −0.011 | (−0.018 to −0.003) | |
| HDL | Sex | .000 | −0.228 | (−0.297 to −0.159) | .000 | −0.008 | (−0.011 to −0.005) |
| Weight | .000 | −0.010 | (−0.013 to −0.008) | .014 | −0.096 | (−0.173 to −0.019) | |
| ApoB | Diastolic blood pressure | .003 | 0.003 | (0.001–0.005) | .044 | 0.002 | (0.000–0.004) |
| Arthritis | .001 | 0.063 | (0.025–0.101) | .001 | 0.084 | (0.036–0.131) | |
| Diabetes | .001 | 0.081 | (0.032–0.130) | .006 | 0.090 | (0.026–0.154) | |
| TC | Sex | .024 | −0.252 | (−0.471 to −0.033) | .031 | −0.253 | (0.483 to −0.023) |
| Age | .000 | 0.017 | (0.011–0.024) | .000 | 0.016 | (0.009–0.024) | |
| Diastolic blood pressure | .013 | 0.013 | (0.003–0.023) | .015 | 0.012 | (0.002–0.021) | |
| Arthritis | .001 | 0.339 | (0.133–0.545) | .002 | 0.225 | (0.002–0.448) | |
| LDL | Diastolic blood pressure | .001 | 0.015 | (0.006–0.024) | .003 | 0.014 | (0.005–0.023) |
| Age at disease onset | .010 | 0.008 | (0.002–0.013) | .014 | 0.008 | (0.002–0.015) | |
| TG | Diabetes | .000 | 0.657 | (0.344–0.970) | .000 | 0.604 | (0.025–0.095) |
| BMI | .000 | 0.068 | (0.033–0.103) | .001 | 0.060 | (0.025–0.095) | |
| ApoB/ApoA1 | Arthritis | .021 | 0.052 | (0.008–0.096) | .019 | 0.066 | (0.011–0.120) |
| hCRP | .000 | 0.015 | (0.007–0.023) | .036 | 0.009 | (0.001–0.018) | |
| Diastolic blood pressure | .000 | 0.004 | (0.002–0.006) | .014 | 0.003 | (0.001–0.005) | |
| Weight | .000 | 0.005 | (0.004–0.007) | .001 | 0.004 | (0.001–0.006) | |
| TC/HDL-C | Sex | .000 | 0.504 | (0.253–0.754) | .006 | 0.016 | (0.005–0.027) |
| Diabetes | .001 | 0.516 | (0.207–0.825) | .008 | 0.460 | (0.121–0.799) | |
| Diastolic blood pressure | .000 | 0.024 | (0.013–0.036) | .006 | 0.016 | (0.005–0.027) | |
| BMI | .000 | 0.109 | (0.077–0.142) | .000 | 0.087 | (0.050–0.125) | |
| LDL/HDL-C | Diastolic blood pressure | .000 | 0.021 | (0.012–0.030) | .001 | 0.019 | (0.008–0.030) |
| Weight | .000 | 0.025 | (0.018–0.032) | .000 | 0.020 | (0.010–0.030) | |
| LDL/ApoB | Hypertension | .016 | −0.172 | (−0.310 to −0.033) | .021 | -0.168 | (−0.310 to −0.026) |
Abbreviation: ApoA1 apolipoprotein A1, ApoB apolipoprotein B, HC healthy controls, HDL-C high-density lipoprotein-cholesterol, LDL low-density lipoprotein, Lp(a) lipoprotein A, TC total cholesterol, TG triglyceride
Stepwise multiple regression analysis was performed after adjustment for sex, age, age at disease onset, disease duration, BMI, PASI and BSA scores at baseline, smoking, alcohol, diabetes, and hypertension. Only the significant variables are shown. p < .05 is considered to be statistically significant