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. 2022 Jan 6;20:24. doi: 10.1186/s12951-021-01232-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — a The schematic of pH-amplified self-illuminating PCN for detecting sentinel lymph nodes with tumor metastasis in vivo. b The images of fluorescence imaging (up) and luminescence imaging (down) in vivo at tumor and normal sides after subcutaneously injected with PCN_6.9. c Representative images of PCN identify metastasis lymph nodes through luminescence and fluorescence in the process of tumor growth. Top: appearance images of different stages of 4T1-GFP subcutaneous tumors. Middle and bottom: Luminescence and fluorescence images of the metastasis lymph nodes in vivo corresponding to the top. Reproduced with permission from [136]. Copyright 2021, Wiley–VCH Verlag GmbH & Co. KGaA, Weinheim