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. 2022 Jan 6;20:24. doi: 10.1186/s12951-021-01232-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a The images obtained by intratumoral injection of ^99mTc-Tilmanocept contrast agent in a patient with breast cancer. Two well-depicted SLNs were clearly seen in all sets of images (white arrow). Reproduced with permission from [85]. Copyright 2021, Society of Nuclear Medicine and Molecular Imaging. b Schematic of ⁸⁹Zr-ferumoxytol and multimodal visualization of lymph nodes (axillary and somatic). Reproduced with permission from [87]. c The reconstructed coronal PET images of inflamed popliteal (Upper) and sciatic (Lower) LNs in the secondary hind limb inflammation model. d Complementary of optical (left) and PET (middle) images of enhancement popliteal and sciatic LNs, indicated by a white arrow. Reproduced with permission from [88]. Copyright 2014, Society of Nuclear Medicine and Molecular Imaging